Percodan vs. Percocet: What’s the Difference and Why Abuse Is Dangerous 

When it comes to prescription painkillers, many people are familiar with Percocet—but fewer know about Percodan, an older but still potent opioid medication. Both drugs are used to manage moderate to severe pain, and both come with serious risks when misused. 

At Pyramid Healthcare, we believe that education plays a crucial role in prevention and recovery. Understanding the difference between Percodan and Percocet and the dangers of abusing them can help people make informed decisions—and know when to seek help. 

What Is Percodan? 

Percodan is a prescription medication that combines two ingredients: 

• Oxycodone – a powerful opioid pain reliever 

• Aspirin – a non-opioid anti-inflammatory pain reliever 

Originally approved in the 1950s, Percodan was once a widely used pain medication. However, due to safety concerns around aspirin (especially in long-term or high-dose use), its popularity has decreased over the years—though it’s still prescribed in some cases. 

What’s the Difference Between Percodan and Percocet? 

While both medications contain oxycodone, the main difference lies in the secondary ingredient: 

• Percodan = Oxycodone + Aspirin 

• Percocet = Oxycodone + Acetaminophen (Tylenol) 

Here’s how that difference matters: 

• Aspirin, found in Percodan, can irritate the stomach and increase the risk of bleeding—especially when taken in high doses or over long periods. 

• Acetaminophen, found in Percocet, is gentler on the stomach but can be toxic to the liver if abused. 

While the oxycodone component drives the risk of addiction and overdose, the second ingredient in each drug poses different health risks when the medication is misused. 

Why Is Percodan Abuse Dangerous? 

Like all opioid medications, Percodan is highly addictive, especially when not taken as prescribed. People may abuse it by: 

• Taking higher doses than prescribed 

• Taking it more frequently 

• Crushing and snorting or injecting it for a faster high 

• Combining it with alcohol or other drugs 

The dangers of abusing Percodan include: 

1. Opioid Addiction 

Oxycodone, the main active ingredient, can quickly lead to physical dependence. Over time, the brain requires more of the drug to feel the same effects, leading to escalating use and addiction. 

2. Overdose Risk 

High doses of oxycodone can slow breathing, cause unconsciousness and result in death. Combining Percodan with other depressants (like alcohol or benzodiazepines) drastically increases this risk. 

3. Internal Bleeding 

Unlike Percocet, Percodan contains aspirin, which can thin the blood and irritate the stomach lining. Chronic abuse can lead to ulcers, gastrointestinal bleeding or even life-threatening hemorrhages. 

4. Organ Damage 

While Percocet abuse risks liver damage due to acetaminophen, Percodan abuse is more likely to cause kidney or gastrointestinal issues related to aspirin toxicity. 

Recognizing Signs of Percodan Abuse 

Someone who is misusing Percodan may show signs like: 

• Drowsiness or nodding off 

• Mood swings or irritability 

• Doctor shopping or asking for early refills 

• Hiding pills or lying about usage 

• Physical withdrawal symptoms when not using 

If these symptoms sound familiar—for yourself or someone you love—you’re not alone, and help is available. 

How Pyramid Healthcare Can Help 

At Pyramid Healthcare, we specialize in treating opioid addiction with compassion and evidence-based care. We understand that opioid use isn’t just about the drug—it’s often connected to pain, trauma, anxiety or mental health struggles. 

Our programs offer: 

• Medical detox to manage withdrawal safely 

• Inpatient and outpatient treatment options 

• Medication-assisted treatment (MAT) when appropriate 

• Therapy for co-occurring disorders 

• Family support and relapse prevention 

Whether it’s Percodan, Percocet or another opioid, recovery is possible—and it starts with reaching out. 

Know the Risks, Get the Help 

Percodan may not be as well-known as Percocet, but the risks are just as real—especially when misused. Whether you’ve been prescribed it for pain or are using it recreationally, it’s important to understand the potential for addiction, overdose and long-term harm. 

At Pyramid Healthcare, we’re here to support anyone ready to break free from opioid abuse and take the first step toward lasting recovery. 

If you’re struggling, we’re ready to help. Contact us today.